Dietary phytosterols impair oncogene signalling via modulation of membrane properties
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چکیده
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منابع مشابه
The dietary flavonoids naringenin and quercetin acutely impair glucose metabolism in rodents possibly via inhibition of hypothalamic insulin signalling.
Secondary metabolites of herbs and spices are widely used as an alternative strategy in the therapy of various diseases. The polyphenols naringenin, quercetin and curcumin have been characterised as anti-diabetic agents. Conversely, in vitro, naringenin and quercetin are described to inhibit phosphoinositide-3-kinase (PI3K), an enzyme that is essential for the neuronal control of whole body glu...
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BACKGROUND In developing countries the prevalence of duodenal ulceration is related to the staple diet and not to the prevalence of Helicobacter pylori. Experiments using animal peptic ulcer models show that the lipid fraction in foods from the staple diets of low prevalence areas gives protection against ulceration, including ulceration due to non-steroidal anti-inflammatory drugs (NSAIDs), an...
متن کاملSerum phytosterols not only from dietary intake.
Phytosterols are common components of plant foods, especially vegetable oils, seeds, nuts and cereals. It is generally assumed that all serum and tissue phytosterols are derived exclusively by intestinal absorption and therefore that serum levels of phytosterols reflect dietary plant sterol intake and intestinal absorption (Miettinen et al. 1990). We suggest that there is another route of intak...
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It is estimated that ischaemic heart disease (IHD) will be the leading contributor to the global burden of disease in the future, moving from fifth place in 1990 to first in 2020. Changes in lifestyle such as increased smoking, sedentary occupations, adoption of high-fat, high animal protein diets and increased exposure to stressful urban situations will increase the risk of IHD and stroke. 2-4...
متن کاملPhytosterols as anticancer dietary components: evidence and mechanism of action.
Phytosterols (PS) or plant sterols are structurally similar to cholesterol. The most common PS are beta-sitosterol, campesterol and stigmasterol. Epidemiologic and experimental studies suggest that dietary PS may offer protection from the most common cancers in Western societies, such as colon, breast and prostate cancer. This review summarizes the findings of these studies and the possible mec...
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ژورنال
عنوان ژورنال: Proceedings of the Nutrition Society
سال: 2021
ISSN: ['1475-2719', '0029-6651']
DOI: https://doi.org/10.1017/s0029665121003098